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Mass Spectrometry of Nucleosides and Nucleic Acids

Mass Spectrometry of Nucleosides and Nucleic Acids

Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments... read full description below.

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ISBN 9780367384685
Barcode 9780367384685
Published 31 July 2019 by Taylor & Francis Ltd
Format Paperback
Author(s) Edited by Banoub, Joseph H.
Edited by Limbach, Patrick A.
Availability Pre-order title, release date has been delayed

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Full details for this title

ISBN-13 9780367384685
ISBN-10 036738468X
Stock Available
Status Pre-order title, release date has been delayed
Publisher Taylor & Francis Ltd
Imprint CRC Press
Publication Date 31 July 2019
Publication Country United Kingdom United Kingdom
Format Paperback
Author(s) Edited by Banoub, Joseph H.
Edited by Limbach, Patrick A.
Category Chemical Spectroscopy, Spectrochemistry
Genetics (Non-Medical)
Biochemistry
Number of Pages 504
Dimensions Width: 178mm
Height: 254mm
Weight Not specified - defaults to 600g
Interest Age 19+ years
Reading Age 19+ years
NBS Text Life Sciences: General
ONIX Text College/higher education;Professional and scholarly
Dewey Code 572.80284
Catalogue Code Not specified

Description of this Book

Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustrates the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers, nucleosides, nucleotides, and adducts. It describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry (MS/MS). Next, the contributors examine mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. They analyze urinary modified nucleosides and explore DNA adducts. They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and examine various uses of electrospray ionization mass spectrometry (ESI-MS). The book reviews recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explores the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examines quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry. The book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates, and concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids. The exciting developments in mass spectrometry technology have fueled incredible advances in our understanding of nucleic acids and their complexes. The contributions presented in this volume capture the range of these advances, helping to inspire new findings a

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Author's Bio

Joseph H. Banoub is a principal scientist and head of the special projects at Fisheries and Oceans Canada, Science Branch. He has been an adjunct professor of biochemistry at Memorial University of Newfoundland since 1984 and an adjunct professor of chemistry since 2006. His present research interests include the uses of tandem mass spectrometry for the structural elucidation of biologically active molecules. Patrick A. Limbach is a professor of chemistry and department head at the University of Cincinnati. His research interests include the development of new mass spectrometry methods for analyzing RNAs, the identification of unknown modified nucleosides, the characterization of RNA-protein complexes, and investigating the role of modified nucleosides in biological systems.

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