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              Books by Nina C. Gonnella

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              LC-NMR: Expanding the Limits of Structure Elucidation

              LC-NMR: Expanding the Limits of Structure Elucidation (Paperback)

              By Gonnella, Nina C.

              • RRP: $130.00
              • $130.00
              • Delayed Release

              The isolation and structural characterization of substances present at very low concentrations, as is necessary to satisfy regulatory requirements for pharmaceutical drug degradants and impurities, can present scientific challenges. The coupling of HPLC with NMR spectroscopy has ...been at the forefront of cutting-edge technologies to address these issues. LC-NMR: Expanding the Limits of Structure Elucidation presents a comprehensive overview of key concepts in HPLC and NMR that are required to achieve definitive structure elucidation with very low levels of analytes. Because skill sets from both of these highly established disciplines are involved in LC-NMR, the author provides introductory background to facilitate readers' proficiency in both areas, including an entire chapter on NMR theory. This book provides guidance in setting up LC-NMR systems, discussion of LC methods that are compatible with NMR, and an update on recent hardware and software advances for system performance, such as improvements in magnet design, probe technology, and solvent suppression techniques that enable unprecedented mass sensitivity in NMR. It also describes numerous NMR collection strategies, including continuous flow, stop flow, solid phase extraction (SPE), loop collection, and capillary electrophoresis. In addition, the author presents an overview of NMR experiments and techniques used in structure elucidation. The text focuses on current developments in chromatographic-NMR integration, with particular emphasis on utility in the pharmaceutical industry. Applications include trace analysis, analysis of mixtures, and detection of degradation products, impurities, metabolites, peptides, and more. The text discusses novel uses and emerging technologies that challenge detection limits as well future directions for this important technique. This book is a practical primary resource for NMR structure determination-including theory and application-that guid
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              ISBN 9780367380274
              Released NZ 30 Aug 2019
              Publisher Taylor & Francis Ltd
              Interest Age 19+ years
              Series Chromatographic Science Series
              Availability
              Pre-order title, release date has been delayed
              View details for this title
              LC-NMR: Expanding the Limits of Structure Elucidation
               

              LC-NMR: Expanding the Limits of Structure Elucidation (Hardback, 2nd New edition)

              By Gonnella, Nina C.

              • RRP: $308.00
              • $308.00
              • Pub Date
                28 Feb 20

              The isolation and structural characterization of substances present at very low concentrations, as is necessary to satisfy regulatory requirements for pharmaceutical drug degradants and impurities, can present scientific challenges. The coupling of HPLC with NMR spectroscopy has ...been at the forefront of cutting-edge technologies to address these issues. LC-NMR: Expanding the Limits of Structure Elucidation presents a comprehensive overview of key concepts in HPLC and NMR that are required to achieve definitive structure elucidation with very low levels of analytes. Because skill sets from both of these highly established disciplines are involved in LC-NMR, the author provides introductory background to facilitate readers' proficiency in both areas, including an entire chapter on NMR theory. The much-anticipated Second Edition provides guidance in setting up LC-NMR systems, discussion of LC methods that are compatible with NMR, and an update on recent hardware and software advances for system performance, such as improvements in magnet design, probe technology, and solvent suppression techniques that enable unprecedented mass sensitivity in NMR. This edition features methods to quantify concentration and assess purity of isolated metabolites on the micro scale and incorporates computational approaches to accelerate the structure elucidation process. The author also includes implementation and application of qNMR and automated and practical use of computational chemistry combined with QM and DFT to predict highly accurate NMR chemical shifts. The text focuses on current developments in chromatographic-NMR integration, with particular emphasis on utility in the pharmaceutical industry. Applications include trace analysis, analysis of mixtures, and structural characterization of degradation products, impurities, metabolites, peptides, and more. The text discusses novel uses and emerging technologies that challenge detection limits as well future directions for this impo
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              ISBN 9781138493407
              Released NZ 28 Feb 2020
              Publisher Taylor & Francis Ltd
              Interest Age 16+ years
              Series Chromatographic Science Series
              Availability
              Available for pre-order, ships once released
              View details for this title
              LC-NMR: Expanding the Limits of Structure Elucidation
               

              LC-NMR: Expanding the Limits of Structure Elucidation (Hardback)

              By Gonnella, Nina C.

              • Imp. $556.99
              • $556.99
              • Not Available Locally

              The book is designed as a reference for chemists, NMR spectroscopists, chromatographers, students, and research professionals who are engaged in the isolation and NMR spectral characterization of complex organic molecules. The content guides the reader through the process of sele...cting the appropriate experiments and isolation systems while providing a foundation of basic theory and spectral interpretation. It discusses new and robust technologies that expand the limits of detection in NMR spectroscopy and includes examples of applications relevant to problems in pharmaceutical development.
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              ISBN 9781439875063
              Replacement this title has been replaced by: 9781138493407
              Released NZ 15 Mar 2013
              Publisher Taylor & Francis Inc
              Interest Age 19+ years
              Series Chromatographic Science Series
              Availability
              Internationally sourced on backorder; allow 4-8 weeks
              View details for this title
              Total 3 jump to: go