Season 5's horrific finale left Dean (Jensen Ackles) alone, as Sam (Jared Padalecki) descended into Hell. Now a different man, Dean vows to stop hunting and devote himself to building a family. Then, mysteriously, Sam reappears, drawing Dean back into hunting. But all is not as i...t seems: Sam is different. A soul-shaking discovery proves Dean's suspicions: this is Sam - but not all of him. As the brothers struggle to reunite, they must also battle deadly supernatural forces: demons, angels, vampires, shape-shifters. And a terrifying new foe called the Mother of All.
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